Mesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF- secretion: effect of the immunomodulator AS101 on this process
نویسندگان
چکیده
Inna Sinuani,* Zhan Averbukh,* Inna Gitelman, Micha J. Rapoport, Judit Sandbank, Michael Albeck, Benjamin Sredni,* and Joshua Weissgarten* Nephrology Division, Assaf Harofeh Medical Center, Zerifin; C.A.I.R. Institute, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan; Department of Molecular Genetics of Development, Ben Gurion University, Beer Sheva; Department of Internal Medicine C, Assaf Harofeh Medical Center, Zerifin; Department of Pathology, Assaf Harofeh Medical Center, Zerifin; and Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan, Israel
منابع مشابه
Mesangial cells initiate compensatory renal tubular hypertrophy via IL-10-induced TGF-beta secretion: effect of the immunomodulator AS101 on this process.
The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and the effect of the immunomodulator AS101 on this process. One hundred forty unilateral nephrectomized and sham-operated male Sprague-Dawley rats were treated by AS101 or PBS before and after surgery. The results show that secretion of IL-10 and TGF-beta by mesangial c...
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